PTEN regulates phospholipase D and phospholipase C
نویسندگان
چکیده
منابع مشابه
Parkin-mediated ubiquitination regulates phospholipase C-γ1
Mutations in parkin cause autosomal recessive forms of Parkinson's disease (PD), with an early age of onset and similar pathological phenotype to the idiopathic disease. Parkin has been identified as an E3 ubiquitin ligase that mediates different types of ubiquitination, which has made the search for substrates an intriguing possibility to identify pathological mechanisms linked to PD. In this ...
متن کاملBrain ischemia decreases phosphatidylcholine-phospholipase D but not phosphatidylinositol-phospholipase C in rats.
BACKGROUND AND PURPOSE Phosphatidylcholine (PC)-phospholipase D (PLD) is an important intracellular signaling pathway in response to a variety of agonists, but little is known about the effects of brain ischemia on the PC-PLD system. We thus have examined the effects of global cerebral ischemia on PLD in rats. METHODS We have examined the effects of global ischemia (decapitation or four-vesse...
متن کاملPhospholipase A 2 and Phospholipase C Activities of Platelets DIFFERENTIAL
Deoxycholate treatment of horse platelets previously labeled in their phospholipids with [“Clarachidonate produces selective conversion of [“Clphosphatidylinositol (PI) to [‘4C]1,2-diacylglycerol. This phospholipase C activity, which has a pH optimum of 7.5, is specific for phosphatidylinositol since other phospholipids or neutral lipids are not affected. Although exogenous Ca2+ is not required...
متن کاملSTUDIES ON PHOSPHOLIPASE C FROM MELIA AZADIRACHTA SEEDS
The activity of phospholipase C in crude enzymatic preparation of Melia azadiracht seeds (Neem seeds) was studied by the use of lecithin as a substrate in aqueous medium. The enzyme activity was found optimum at pH 2.5 and temperature 35?C. The phospholipase C was found heat labile, being inactivated 88% within 10 minutes at 90°C
متن کاملSTUDIES ON PHOSPHOLIPASE C FROM MELIA AZADIRACHTA SEEDS
3,5- dinitrobenzoyl chloride-pyridine system has been used for dehydration of aldoximes and carboxamides at room temperature
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2007
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddm063